ERK activation, Pten loss, and Tyrp2 expression also were seen in the YUMM1.7 melanoma cell line derived from induced tumors in the Braf Pten mouse model [47], whereas Sox10 and Tyrp2 were expressed by human A375P cells, representative of primary cutaneous human melanoma cell lines (Figure 4B). The gene discussed is PTEN; the disease is melanoma.