Importantly, Loxl3 is required for melanoma metastasis, both lymphatic, determined by the dramatic decrease of lymph node invasion in Loxl3 KO mice, and visceral, supported by reduced lung metastatic burden in experimental metastasis assays in syngeneic mice upon tail vein injection of B16-F10 cells silenced for Loxl3. Here, LOXL3 is linked to melanoma.