However, Loxl3 silencing did not induce cell apoptosis (Figure 4F), as is the case in human melanoma cells [38], but promoted DNA damage, determined by the accumulation of γH2AX and 53BP1 foci in Loxl3-depleted MeL3 cells compared to control cells (Figure 4G,H). Here, LOXL3 is linked to melanoma.