LOXL3 and melanoma: Even if an increased accumulation of DNA damage was seen in the absence of Loxl3 in these cell lines, no cell cycle abnormalities were detected, indicating that mouse melanoma cells were able to survive without Loxl3 in the long term, either because the accumulation of DNA damage was lower than in the human setting, or mouse cells could activate a somewhat functional DNA damage response that prevented additional genomic aberrations in established cell cultures.