To understand the molecular mechanisms by which Loxl3 contributes to mouse melanomagenesis, we derived primary cell lines from our Loxl3 melanoma mouse model as detailed in the Materials and Methods section and Figure 4A. Several cell lines were established from melanomas grown on Loxl3 WT mice, while no single cell line was derived from those grown on Loxl3 KO animals, despite numerous attempts. The gene discussed is LOXL3; the disease is melanoma.