BRAF and melanoma: The molecular characterization of the established cell lines demonstrated that only one cell line, named MeL3, recapitulated the expected protein expression pattern; i.e., the presence of melanocytic lineage markers Tyrp2 and Sox10, enhanced ERK phosphorylation due to Braf activation, and Pten loss, while most melanoma-derived cell lines, such as 137d, did not (Figure 4B).