In a similar fashion, Seibold et al. investigated VEGF and its receptor tyrosine kinase 1 (FLT-1) in patients with locally advanced squamous cell carcinoma who had been treated with adjuvant radiotherapy or chemo-radiotherapy, which showed a correlation between VEGF expression and loco-regional control (LRC), metastasis-free survival, and overall survival (OS) [14]. This evidence concerns the gene VEGFA and squamous cell carcinoma.