Besides preventing T-cell adhesion to vessel wall and subsequent extravasation to the tumor site [30], VEGF also inhibits helper T-cell recruitment to the tumor site [38] and promotes immunosuppressive cells such as Tregs [30,39] and myeloid-derived suppressor cells (MDSCs) [40] by binding with VEGFR-2. The gene discussed is VEGFA; the disease is neoplasm.