Furthermore, neratinib plus capecitabine as compared with lapatinib and capecitabine was also associated with a longer PFS (12.4 months vs. 8.3 months), and lower cumulative incidence of interventions for CNS disease (25.5% vs. 36.0%), and progressive CNS disease (26.2% vs. 41.6%), suggesting that such a combined treatment could be a valuable option in patients with CNS involvement from HER2-positive metastatic BC [10]. This evidence concerns the gene ERBB2 and breast cancer.