This phase 3 trial included chemotherapy-naive patients with International Federation of Gynecology and Obstetrics (FIGO) IIB-IV ovarian cancer and upfront debulking surgery that were randomly assigned (2:1) to receive six cycles of carboplatin and paclitaxel followed by maintenance nintedanib (a tyrosine kinase inhibitor targeting VEGFR) or placebo. This evidence concerns the gene KDR and ovarian cancer.