In many mouse models of cancer (e.g., breast cancer, colon cancer, melanoma, etc.), injecting cGAMP results in the accumulation of macrophages that secrete tumor necrosis factor (TNF)-alpha and chemokines, thereby recruiting T-cells and suggesting a role for macrophages in STING-induced anti-tumor effects [18]. The gene discussed is STING1; the disease is colonic neoplasm.