However, in a recent study, Tang et al. [11], using STING-deficient and STING-proficient non-malignant B-cells and a chronic lymphocytic leukemia mouse model, showed that STING-deficient cells were indeed more responsive to B-cell receptor activation than their STING-proficient counterparts. Here, STING1 is linked to B-cell chronic lymphocytic leukemia.