Nodal lymphomas include anaplastic lymphoma kinase (ALK)-positive anaplastic large cell lymphoma (ALCL); ALK-negative ALCL; angioimmunoblastic T-cell lymphoma (AITL); and peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). The gene discussed is ALK; the disease is mature T-cell and NK-cell non-Hodgkin lymphoma.