The major biallelic inactivation of BRCA1 and/or BRCA2 in uLMS, which is one of the most proficient biomarkers for the response of poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors, is somatic homozygous deletion of BRCA2, although germline pathogenic or likely pathogenic mutations, along with loss of heterozygosity (LOH), are major causes of biallelic inactivation of BRCA1/2 in other gynecologic malignancies, including ovarian cancer [49]. The gene discussed is BRCA1; the disease is ovarian carcinoma.