The crucial role of DCs in cancer immune response has been additionally demonstrated as cancer patients with more infiltration of cDC1 have a lower incidence of metastasis in oral, head and neck tumors [94] This could be related to the association of tumor-infiltrated cDC1 with the abundance of CD8+ T cells in the TME [64,95]. This evidence concerns the gene MPPE1 and head and neck neoplasm.