Immature DCs can be recruited into the TME, attracted by tumor-secreted factors such as CCL2, CCL20/MIP3a, CCL25, CCL5, CXCL12, CXCL1, and CXCL5, while mature DCs reside in areas surrounding the tumor [2,62,63]. The gene discussed is CXCL12; the disease is neoplasm.