SOX2 and urinary bladder carcinoma: In addition, ChlA-F, a conformation-derivative of Chel A isolated from Goniothalamus cheliensis Hu, promotes SOX2 ubiquitination and protein degradation by enhancing the mRNA stability of E3 ligase USP8 and also inhibits SOX2 protein translation by activating c-Jun-miR-200c, thus suppressing the invasion of bladder cancer cells [165].