Additionally, in glioblastoma stem-like cells, SOX2 and OCT4 cooperate to promote immunosuppressive TME by activating immunosuppressive transcriptome mediated by the BRD4/H3k27Ac axis, which includes various immunosuppressive checkpoint molecules (i.e., PD-L1, CD70, A2aR, TDO), cytokines, and chemokines involved in T-cell apoptosis, Treg infiltration, and M2 macrophage polarization [149]. Here, SOX2 is linked to glioblastoma.