In detail, SOX2 negatively regulates the transcription of IFNB1 and IFNI target CXCL10 induced by STING agonist cGAMP and intracellular poly (dA:dT), and accelerates autophagy-mediated STING degradation, leading to a decrease of CD8+T cells infiltration and a relative increase of PD-1high CD8+T cells population, which represents an immune exhaustion state, eventually contributing to tumor growth [144]. The gene discussed is CD8A; the disease is neoplasm.