Through comparatively analyzing the impact of distinct genetic backgrounds in prostate cancer on the composition of immune cells within TME, Marco Bezzi et al. uncovered that the loss of Zbtb7a up-regulates the CXCL5 expression by inducing SOX9 transcriptional activity, thus increasing the recruitment of polymorphonuclear MDSCs in the Pten-deficient tumors and facilitating tumor progression [155]. The gene discussed is SOX9; the disease is prostate carcinoma.