SOX2 and non-small cell lung carcinoma: By developing genetically engineered mouse models of non-small cell lung cancer, Gurkan Mollaoglu et al. found that the overexpressed SOX2 and the inhibition of NKX2-1 by SOX2 synergistically promote tumor-associated neutrophil (TANs) recruitment through up-regulating CXCL5 expression, facilitating adeno-to-squamous transdifferentiation and squamous tumorigenesis [148].