These include gene fusions in RUNX1-RUNX1T1 (runt-related transcription factor 1), CBFB-MYH11 (core-binding factor subunit beta–myosin heavy chain 11), acute promyelocytic leukemia (APL) with PML-RARA (promyelocytic leukemia/retinoic acid receptor alpha), MLLT3-KMT2A (mixed-lineage leukemia translocated to chromosome 3- lysine methyltransferase 2A), DEK-NUP214 (DEK oncogene–nucleoporin 214), and an inversion that repositions a distal GATA2 enhancer to activate MECOM expression. The gene discussed is RARA; the disease is acute promyelocytic leukemia.