The revised 2017 WHO classification has myeloid neoplasms with germline mutations in RUNX1, CEBPA, DDX41 (DEAD-box helicase 41), RUNX1, GATA2 (GATA binding protein 2), ETV6 (ETS variant transcription factor 6), SRP72 (signal recognition particle 72), and ANKRD26 (ankyrin repeat domain 26) as markers of AML predisposition [29,56,57]. This evidence concerns the gene DDX41 and acute myeloid leukemia.