IDH1 and acute myeloid leukemia: Additional genes with varying gene mutation frequency in AML patients include mixed-lineage leukemia (MLL), neuroblastoma RAS (NRAS), Wilms’ tumor type 1 (WT1), v-KIT, runt-related transcription factor (RUNX1), and iso-citrate dehydrogenase (IDH1) [37,38,39,40,41,42].