CD274 and cancer: For example, antibodies of anti-program-death 1 (PD-1) or anti-program death-ligand 1 (PD-L1) (i.e., nivolumab and pembrolizumab) can disrupt the interaction between PD-1 and PD-L1, an interaction which inactivates T cells and thus permits cancer cells to evade the human immune system [4].