Lazertinib, a third-generation TKI targeting activating and T790M EGFR mutations, showed important clinical activity in EGFR-mutated NSCLC patients as a second-line treatment after progression to a first- or second-generation TKI [60] and its efficacy, in combination with amivantamab after progression to osimertinib treatment, was demonstrated [61]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.