In addition, in recurrent or metastatic androgen receptor-overexpressing salivary duct carcinoma, now there is clear evidence of clinical benefit from androgen deprivation therapy [7] or combined androgen blockade [8]; there is also an emerging rationale for a clinical trial of ADT/CAB in the adjuvant setting for AR-overexpressing salivary duct carcinoma at high risk of disease recurrence. Here, AR is linked to salivary duct carcinoma.