A side-by-side in vivo comparison of [18F]FPyPARP to [18F]FTT and [18F]PARPi revealed a partial shift to renal clearance, but since tumor-to-liver ratios remained well below “1”, it is likely that further modifications and a stronger shift to renal clearance would be required for PARP1 imaging of abdominal lesions. Here, PARP1 is linked to neoplasm.