Spino et al. found that IDH-mut gliomas have significantly higher Notch ligand delta-like 3 (DLL3) RNA (p < 1 × 10−15) and protein by immunohistochemistry (IHC) (p = 0.0014 and p < 4.3 × 10−6), whereas expression was patchy, low, or absent in IDH-wt GBM [64]. This evidence concerns the gene IDH2 and central nervous system cancer.