2-HG inhibition by treatment with a specific IDH1R132H inhibitor alone or in combination with radiation and temozolomide (TMZ) substantially prolonged survival of IDH1-mut glioma-bearing mice, increased PD-L1 expression levels to similar levels as observed in IDH-wt gliomas, contributing in also generating an anti-glioma immunity [35]. This evidence concerns the gene CD274 and central nervous system cancer.