IDH1 and neoplasm: Moreover, in different syngeneic IDH1-mut tumor models, 2-HG inhibited the development of antitumor T-cell immunity induced by IDH-1 vaccination, adoptive T-cell transfer, and checkpoint blockade while pharmacological inhibition of the neomorphic enzymatic function of mut-IDH1 by administration of BAY-1436032 alleviates intratumoral immune suppression [32] (Table 1).