Conversely, IDH-wt low-grade astrocytoma harboring one or more of the three genetic features of classic GBM (TERT promoter mutation, epidermal growth factor receptor gene amplification, or combined gain of entire chromosome 7 and loss of entire chromosome 10), will be labeled as GBMs, carrying a very similar dismal prognosis [18]. This evidence concerns the gene IDH2 and astrocytoma (excluding glioblastoma).