Zhang et al. have shown that glioma cells harboring IDH1 mutation acquire resistance to natural killer (NK) cell-mediated lysis due to the epigenetic silencing of NKG2D ligands ULBP1 and ULBP3 by 2-HG-induced hypermethylation [50], making IDH-mut tumors less vulnerable to NK-cell-mediated lysis as compared to IDH-wt. This evidence concerns the gene IDH2 and central nervous system cancer.