IDH2 and astrocytoma (excluding glioblastoma): Grade 4 gliomas (both IDH mutated astrocytomas and IDH wildtype GBMs): patients with a good Karnofsky performance status (KPS > 70) and age less than 65 years are treated with six weeks concomitant chemoradiation followed by adjuvant temozolomide (the so-called “Stupp protocol”) [5,21].