IDH3A and central nervous system cancer: In the WHO classification of adult diffuse gliomas, the status of two molecular alterations–namely, hotspot mutations in the genes coding for the isocitrate dehydrogenase [IDH] isoforms 1 and 2, and the chromosomal codeletion 1p/19q, an unbalanced translocation resulting in the complete loss of the 1p and 19q chromosomal arms, is crucial in glioma taxonomy, irrespective of the histological grading.