KDR and ovarian carcinoma: For example, the three-arm, placebo-controlled, phase III GOG-218 trial enrolled 751 newly diagnosed epithelial ovarian cancer patients to receive carboplatin-paclitaxel with or without bevacizumab, and initially found no prognostic or predictive association with VEGF-A, VEGFR-2, NRP-1 or MET [49].