Although expression of ERα in HGSOC has been reported [16,17,18] and was shown to be positively correlated with lymphovascular space invasion (LVSI), a prognostic indicator of poor survival [19], a large study conducted by the Ovarian Tumor Tissue Analysis consortium in 1742 HGSOC cases showed that ERα was not associated with improved HGSOC survival [18]. This evidence concerns the gene ESR1 and ovarian neoplasm.