A recent study using established prostate cancer organoids derived from Pten-/-R26ERG mice showed that ERG knockout dampens AR-dependent gene expression without altering AR binding to DNA or H3K27 acetylation at enhancers, but causing the loss of critical AR coregulators, such as NCOA3, and the basal transcriptional machinery [109]. The gene discussed is PTEN; the disease is prostate carcinoma.