For instance, an independent mechanism driving PCa tumorigenesis was uncovered in PCa tumors overexpressing SPINK1 with the activation of a gastrointestinal circuit driven by the transcription factors hepatocyte nuclear factor 4-gamma (HNF4G) and hepatocyte nuclear factor 1-alpha (HNF1A) [182]. The gene discussed is HNF4G; the disease is posterior cortical atrophy.