TMPRSS2-ERG fusions are not detected in the normal prostate epithelium or in benign prostatic hyperplasia but are found in premalignant prostatic intraepithelial neoplasia (PIN) lesions, suggesting a role in the early stages of prostate cancer development [88,89,90,91,92,93]. The gene discussed is TMPRSS2; the disease is Familial prostate cancer.