Activation of P2X7R in melanoma, colon cancer, and neuroblastoma cancer cell lines induces secretion of VEGF [14,70,71], while its activation in breast cancer cell lines and leukocytes leads to an increase in the activity of MMP-3, MMP-9, and MMP-13 [14,72,73,74]. The gene discussed is VEGFA; the disease is melanoma.