NLRP3 have been shown to promote the onset/development of several cancers, including breast cancer, where it promotes the infiltration of myeloid cells, such as tumour-associated macrophages and myeloid-derived suppressor cells (MDSCs), which are key components of the immunosuppressive TME, favouring an IME and therefore promoting tumour initiation/progression [122]. The gene discussed is NLRP3; the disease is neoplasm.