MRC1 and neoplasm: Porka et al., identified two somatic events in MMR genes in 11 out of 14 tumors and a somatic mutation and LOH in 10 out of 11 (4/10 in MLH1, 5/10 MSH2, and 1/10 PMS2), whereas only one tumor was characterized as having two somatic mutations (MSH6) [56].