Following this line of inquiry, variants in BUB1 and BUB3 [79], SETD2 [80], WRN [81], BARD1 [81], MCPH1 [81], and REV3L [81] have been found in the germline analysis of LLS cases, linking the mutation of WRN, BARD1, MCPH1, and REV3L for the first time with CRC. The gene discussed is REV3L; the disease is colorectal carcinoma.