Following this line of inquiry, variants in BUB1 and BUB3 [79], SETD2 [80], WRN [81], BARD1 [81], MCPH1 [81], and REV3L [81] have been found in the germline analysis of LLS cases, linking the mutation of WRN, BARD1, MCPH1, and REV3L for the first time with CRC. This evidence concerns the gene MCPH1 and colorectal carcinoma.