FLT3 and leukemia: Accordingly, CDDD11-8 inhibited the proliferation of leukemia cell lines with FLT3-ITD and MLL fusions (MV4-11 and MOLM-13 cells) more potently relative to cell lines lacking these mutations (e.g., U937) or those harboring either one of these genetic aberrations (e.g., PL21 and THP-1, Table 1).