TPA (12-O-tetradecanoylphorbol-13-acetate) has been reported to activate PKCα/ERK/NF-κB-dependent matrix metalloproteinase 9 (MMP-9) expression and elicit glioblastoma cell migration, which can be prevented through downregulating PKCα expression [76]. The gene discussed is MMP9; the disease is glioblastoma.