AKT1 and neoplasm: The inhibitory effect of lupeol in oral cancer cells (UPCI:SCC131 and UPCI:SCC084) was evidenced by the suppression of EGFR phosphorylation and its downstream proteins, such as protein kinase B (Akt), I kappa B (Ik B) and NF-k B. Lupeol was further investigated in patient-derived tumor tissues.