Artesunate suppressed phosphorylation of certain proteins involved in cell survival (p38, ERK, STAT5, CREB) and induced expression of SOCS-1 protein and apoptosis via caspase 3 activation in chronic myeloid leukemia (CML) xenograft mouse model. Here, SOCS1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.