Based on the retrospective analysis of 411 patients, the nomogram included 6 significant variables: KPS (70–80 vs. <70), the biological subtype of BC (luminal A, luminal B, triple-negative, HER2 positive), LEP (yes vs. no), number of BM (≤3 vs. >3), ECM controlled (CR, PR, SD) vs. uncontrolled (PD) and disease-free survival (>36 vs. ≤36 months). The gene discussed is ERBB2; the disease is breast cancer.