The water-soluble polysaccharide obtained from barley grains with different molecular weight and monosaccharide composition was also found to inhibit proliferation of human colon cancer cells HT-29 in a time- and dose-dependent manner by inducing HT-29 apoptosis through ROS (reactive oxygen species)-JNK (c-Jun N-terminal kinase) and NF-B (nuclear factor-B)-mediated caspase pathways [46]. Here, MAPK8 is linked to colonic neoplasm.