Here, we used transgenic GnRH‐green fluorescent protein (GFP) mice,26 treated with chronic DHT from PND21 to model the hyperandrogenism of PCOS that promotes reproductive impairments and a metabolic syndrome,13, 15, 27 to assess LH secretion dynamics and anatomical evidence for GABAergic innervation to GnRH neurons. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.