VPS13A and chorea-acanthocytosis: The VPS13 proteins, which are conserved across all eukaryotes from yeasts to humans, have been of great biomedical interest because mutations in any of the four human VPS13 genes (VPS13A–VPS13D) give rise to severe neurological disorders including chorea-acanthocytosis, which shares some phenotypes of Huntington's disease, as well as an early onset form of Parkinson's disease (Lesage et al., 2016; Rampoldi et al., 2001; Ueno et al., 2001).