Increased levels of plasma/serum ANGPT2 have been reported in patients with various solid cancers, where they correlate with advanced tumor stage, recurrence, and presence of metastases (Sfiligoi et al, 2003; Takanami, 2004; Helfrich et al, 2009; Detjen et al, 2010; Goede et al, 2010; Hacker et al, 2016; Dong et al, 2018). Here, ANGPT2 is linked to neoplasm.