Consistent with this idea, PMS and human KCNMA1/BK mutations are associated with several shared phenotypes including: autism, developmental delay, intellectual disability, hypotonia, seizures, and gastrointestinal defects (i.e. vomiting, constipation, or diarrhea) (Bailey et al., 2019; Laumonnier et al., 2006; Phelan and McDermid, 2012; Soorya et al., 2013; Witmer et al., 2019). This evidence concerns the gene KNG1 and Global developmental delay.