Of these potential binding partners, we focus on CaV1 because human CACNA1C (which encodes a CaV1 α-subunit) is mutated in Timothy Syndrome (TS), a rare monogenic form of ASD (Splawski et al., 2005; Splawski et al., 2004), and polymorphisms linked to CACNA1C are associated with multiple psychiatric disorders (Psychiatric Genomics, 2013). Here, CACNA1C is linked to Timothy syndrome.