VEGFA and asthma: However, recent studies have shown that carboxypeptidase A3 can cleave angiotensin and form angiotensin-(1-9), suggesting that the protease may contribute to vasodilation and immune cell infiltration in asthma [66], and cathepsin G has been shown to cleave the alarmins IL-18 and IL-33 as well as the stem cell factor (SCF), IL-3, IL −6, IL-7, IL-15, IL-31, and vascular endothelial growth factor (VEGF), suggesting a regulatory role in asthmatic inflammation (Figure 1) [67].