Finally, LTE4 promotes bronchoconstriction, increases the number of circulating immune cells [50], the migration of ILC2 and cytotoxic T cells, and the production of IL-13, IL-8, granulocyte-macrophage colony-stimulating factor (GM-CSF), and amphiregulin; suggesting that it contributes to the immune cell accumulation and airway remodeling observed in asthma [51,54]. This evidence concerns the gene CSF2 and asthma.