CXCL1 and neoplasm: Tumor-infiltrating mast cells promote tumor growth through the release of IL −1β and blood microvessel formation through CXCL1 and VEGF-A; they promote cancer metastasis through the release of IL −8 and suppress T-cell immunity to cancer through the expression of programmed death-ligand 1 (PD -L1) [119–121].