Cellular and molecular analysis using human prostatic cancer PC3 cells showed arrest of the cell cycle at the pre-G1 phase, enhanced apoptosis and necrosis, reduced mitochondrial membrane permeability, reduced Bcl-2, NF-kB, TNF-α levels, and increased Bax, caspase, and p53 levels upon treatment with SV conjugated CUR phytosomes. The gene discussed is TNF; the disease is prostate cancer.