Later on, Lee et al. [47] described a series of primary intracranial sarcomas with DICER1 mutations, showing that the most common location is in the cerebral hemispheres, that histologically they invariably contain intracytoplasmic eosinophilic granules, and that, in addition to the DICER1 mutations, TP53 mutations and Ras pathway activation were common, and can occur in the setting of Neurofibromatosis type 1. The gene discussed is DICER1; the disease is neurofibromatosis type 1.