Here, for the first time, we systematically investigated the expression of membrane-bound and soluble OX40 and OX40L in the peripheral blood of MG patients at different stages, as well as the effect of immunosuppressive agents (both glucocorticoids and immunosuppressants) on sOX40 and sOX40L levels. Here, TNFRSF4 is linked to myasthenia gravis.