AKT1 and cancer: Furthermore, after using 3-Methyladenine (3-MA), an inhibitor of PI3K, the increased levels of phosphorylated PI3K and Akt were decreased, and DNMT3A, DNMT3B, KCND3, and KCNQ1 levels were also rescued compared with AGS and SW480 cancer cell media treated cardiomyocytes (Figures 7C,D).