RHOA and melanoma: The results showed that the genes in BJ_Mod4 are mainly enriched in the FoxO signaling pathway, Melanoma, Glioma, Longevity regulating pathway, Autophagy, etc. The BJ_Mod7 is enriched in Pancreatic secretion, Neurotrophin signaling pathway and response to interferon, GTPase activity, GTP binding, nucleoside binding GO terms, etc. In the Neurotrophin signaling pathway, BJ can activate the MSK1 and RhoA driver genes, which promotes the cell survival and axonal outgrowth (Figure 6E).