Mutations in the genes expressing sarcomere protein components including MYH7, MYBPC3, and MYL2 are found in a significant number of patients with dilated or hypertrophic cardiomyopathy and thus, pathogenic variants in these genes are recommended by ACMG to be reported even as a secondary or incidental finding in genome or exome sequencing (25). This evidence concerns the gene MYL2 and hypertrophic cardiomyopathy.