Observations link the pathological mechanisms underlying several different genetic forms of cerebellar ataxia to TRPC3-orchestrated dysfunction in Ca2+ signaling (Konur and Ghosh, 2005; Paulson, 2009; Soong and Paulson, 2007; Kim 2013; Becker et al., 2011; Dunleva et al., 2015; Fogel et al., 2015; Fogel et al., 2016; Prestori et al., 2020). This evidence concerns the gene TRPC3 and aceruloplasminemia.