Furthermore, the level of expression of circMTO1 (hsa circ 007874) in monastrol-resistant breast cancer cell lines is substantially lower than in monastrol-sensitive breast cancer cell lines, and uncontrolled expression of circMTO1 will reverse monastrol resistance through the circRNA/TNF receptor-associated factor 4 (TRAF4)/Eg5 pathway. This evidence concerns the gene TRAF4 and breast carcinoma.