No statistical difference (p > 0.05) was found in age, education, males, smokers, drinkers, take exercise, hobbies, hypertension, diabetes, total brain volume, left hippocampus volume, right hippocampus volume, CC_anterior volume, CC_Central volume, baseline MoCA score, MoCA score during follow-up, MoCA change value, ALT score during follow-up, and ALT change value between the two groups. The gene discussed is GPT; the disease is diabetes mellitus.