A recent research indicated that the cGAS/STING cascade was remarkably suppressed in peripheral blood CD8+ T cells from tumor patients, STING agonist treatment promoted CD8+ T cell stemness from patients with cancer; in addition, elevated STING activation enhanced oncotherapy of CAR-T cells in a xenograft model (Li W et al., 2020). The gene discussed is STING1; the disease is neoplasm.