Recent studies suggested that multiple oncotherapies were related to activation of the cGAS/STING pathway, as the tumor-derived DNA was detected in the cytoplasm of the tumor-infiltrating dendritic cells (DCs); meanwhile, tumor-specific antigen presentation and cytotoxic T-cell activation were increased (Chen et al., 2016b; Deng et al., 2014; Wang et al., 2017) (Figure 2). Here, CGAS is linked to neoplasm.