Meanwhile, our GSEA analysis showed that the malignant hallmarks of tumors, including Angiogenesis, DNA repair, Coagulation, IL-6/JAK/STAT3 signaling, KRAS signaling, PI3K/AKT/MTOR signaling, TGFβ signaling were significantly related to the CL2 subgroup in TCGA-GBM cohort (Figures 3G–M). This evidence concerns the gene TGFB1 and glioblastoma.