In the TCGA-GBM cohort, a significant increase in the expression of checkpoint inhibitor-related genes was found in the CL2 group compared to the CL1 group (Figure 4G), while the expression of major histocompatibility complex (MHC) (Figure 4H) and stimulator-related genes (Figure 4I) did not show significant differences. This evidence concerns the gene HLA-C and glioblastoma.