NPHS1 and familial nephrotic syndrome: NPHS1 genetic variants are causative of congenital nephrotic syndrome of the Finnish type (Kestilä et al., 1998), in which podocytes from human embryos carrying an NPHS1 mutation displayed reduced Nephrin expression (20%) and altered (cilia-specific) α-Tubulin distribution, indicative of incomplete podocyte maturation (Vukojevic et al., 2018).