Additional variants in endocytosis proteins important for SD maintenance and function have been associated with nephrotic syndrome in patients, including variants in Myosin-1E (Myo1E; binds Dynamin and Synaptojanin) (Mele et al., 2011; Sanna-Cherchi et al., 2011), and CD2AP (a major binding partner of Endophilin) (Kim et al., 2003). The gene discussed is CD2AP; the disease is nephrotic syndrome.