RPH3A and focal segmental glomerulosclerosis: Moreover, expression of the RPH3A-RAB3 complex was decreased in podocytes of a mouse model for FSGS (growth-hormone transgenic mice), and RPH3A protein expression was increased in biopsied tissue from patients with glomerular diseases, where the expression inversely correlated to the amount of urinary proteins (Rastaldi et al., 2003).