Despite that, KRAS and TP53 mutations are both important genetic events in non-small cell lung cancer (NSCLC) and pancreatic ductal adenocarcinoma (PDAC); NSCLC tumors exhibited enhanced BCAA uptake, while PDAC tumors showed decreased BCAA uptake (Mayers et al., 2016). Here, TP53 is linked to pancreatic ductal adenocarcinoma.