Moreover, BECN1 was experimentally validated in a previous article as an important initiator molecule of autophagy and inhibited the growth of lung adenocarcinoma cells (Han et al., 2018) and it also plays a role in the regulation of the immune system (Cui et al., 2016), while PTGS2 was also confirmed as a prognostic biomarker for lung adenocarcinoma (Castelao et al., 2003). This evidence concerns the gene BECN1 and lung adenocarcinoma.