Herein, we applied stepwise regression analysis to compose a clinical prognostic signature for BLCA patients with 13 IMRGs (TCIRG1, CTSE, ATP6V0A1, CYP2C8, RNF19A, CYP4Z1, YPEL5, PLOD1, BMP6, CAST, SCD, IFNG, and ASIC3). Here, CAST is linked to bladder transitional cell carcinoma.