Herein, we applied stepwise regression analysis to compose a clinical prognostic signature for BLCA patients with 13 IMRGs (TCIRG1, CTSE, ATP6V0A1, CYP2C8, RNF19A, CYP4Z1, YPEL5, PLOD1, BMP6, CAST, SCD, IFNG, and ASIC3). The gene discussed is CTSE; the disease is bladder transitional cell carcinoma.