TTN and bladder transitional cell carcinoma: In BLCA samples, the 20 genes with the highest mutation rate were TP53, TTN, KMT2D, MUC16, ARID1A, KDM6A, PIK3CA, SYNE1, RB1, HMCN1, FGFR3, RYR2, KMT2C, MACF1, EP300, FLG, FAT4, STAG2, ATM and OBSCN (Figures 4A–D).