In BLCA samples, the 20 genes with the highest mutation rate were TP53, TTN, KMT2D, MUC16, ARID1A, KDM6A, PIK3CA, SYNE1, RB1, HMCN1, FGFR3, RYR2, KMT2C, MACF1, EP300, FLG, FAT4, STAG2, ATM and OBSCN (Figures 4A–D). Here, EP300 is linked to bladder transitional cell carcinoma.