In BLCA samples, the 20 genes with the highest mutation rate were TP53, TTN, KMT2D, MUC16, ARID1A, KDM6A, PIK3CA, SYNE1, RB1, HMCN1, FGFR3, RYR2, KMT2C, MACF1, EP300, FLG, FAT4, STAG2, ATM and OBSCN (Figures 4A–D). The gene discussed is RYR2; the disease is bladder transitional cell carcinoma.