The VEGF-C enhances the formation of tumor lymphatic vessels surrounding tumors and activates the integrin α4β1 on the endothelium of the tumor lymphatic vessels which interacts with vascular cell adhesion molecule 1 (VCAM-1) to promote cancer cell migration and LN metastasis (Garmy-Susini et al., 2013). Here, VCAM1 is linked to neoplasm.