Meanwhile, the phosphorylation of CBX3 at Ser176 and CRBE1 at Ser142 were down-regulated and up-regulated in CRC cells versus normal cells, respectively (Figure 5F), and CBX3 and CREB1 probably targeted 8.7 and 2.9% of all differentially expressed nuclear genes (Figure 5H). This evidence concerns the gene CREB1 and colorectal carcinoma.