On the other hand, the binding motifs of TFs JUN, SOX4, JUND, GATA2, ASCL2, and ELF1 were only opened in CRC cells and potentially regulated 28, 16, 12, 6, 4, and 2% of up-regulated nuclear genes in CRC cells, respectively (Figures 5B,D). This evidence concerns the gene SOX4 and colorectal carcinoma.