PRKN and serum lipopolysaccharide activity: Since PINK1-Parkin mitophagy is a major quality control mechanism for mitochondria (Kubli et al., 2013; Piquereau et al., 2013; Sun et al., 2018b), we next examined whether myocardial MAMs are also subjected to regulation via the PINK1-Parkin signaling axis during endotoxemia.