Recently, biological studies have pointed to aberrant rat sarcoma virus (RAS)/rapidly accelerated fibrosarcoma protein (RAF)/mitogen-activated and extracellular-signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway activation as being critical for cancer progression, proliferation, and survival, as well as for targeted therapy resistance mechanisms [36]. This evidence concerns the gene MAP2K7 and cancer.