Taken together, our gene expression analysis of PBMCs from hepatitis B related HCC patients has demonstrated the presence of alterations, and additional qRT-PCR verification and receiver operating characteristic curve analysis have revealed that seven genes are differentially expressed in the patients with HCC (TYMP, TYROBP, CD14, TGFBI, LILRA2, GNLY, and GZMB). Here, GNLY is linked to hepatocellular carcinoma.