With the progress regarding molecular biology techniques such as RNA immunoprecipitation, RNA pull-down and luciferase reporter assays, the competing endogenous RNA (ceRNA) (lncRNA-miRNA-mRNA) network has been universally acknowledged to exert a crucial impact on physiological and pathological processes that PCGEM1 mediates in cancers (Figure 1) (58). This evidence concerns the gene PCGEM1 and cancer.